Assay Detail
Functional
CHEMBL4328859
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Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of novel phenol ether derivatives as non-covalent proteasome inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.49 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4441072 | — | — | 1 | 8.54 |
| CHEMBL2346855 | — | — | 1 | 8.53 |
| CHEMBL4587043 | — | — | 1 | 8.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4441072 | — | IC50 | = | 2.87 | nM | 8.54 |
| CHEMBL2346855 | — | IC50 | = | 2.95 | nM | 8.53 |
| CHEMBL4587043 | — | IC50 | = | 3.91 | nM | 8.41 |