Assay Detail
Binding
CHEMBL4328892
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human COX-2 expressed in Baculovirus infected sf9 cells using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition measured after 10 mins by ELISA
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Medicinal chemistry of vicinal diaryl scaffold: A mini review.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.33 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL52760 | — | — | 1 | 8.70 |
| CHEMBL865 | VALDECOXIB | 4.0 | 1 | 8.30 |
| CHEMBL92154 | — | — | 1 | 8.12 |
| CHEMBL4533150 | — | — | 1 | 7.96 |
| CHEMBL4473838 | — | — | 1 | 7.70 |
| CHEMBL274893 | SC-57666 | — | 1 | 7.58 |
| CHEMBL89429 | — | — | 1 | 7.58 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 7.40 |
| CHEMBL4527106 | — | — | 1 | 7.22 |
| CHEMBL328837 | — | — | 1 | 7.10 |
| CHEMBL109017 | — | — | 1 | 6.96 |
| CHEMBL325755 | — | — | 1 | 5.73 |
| CHEMBL43511 | — | — | 1 | 4.99 |
| CHEMBL55189 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL52760 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL865 | VALDECOXIB | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL92154 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL4533150 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4473838 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL274893 | SC-57666 | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL89429 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL118 | CELECOXIB | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4527106 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL328837 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL109017 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL325755 | — | IC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL43511 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL55189 | — | IC50 | > | 100000.0 | nM | - |