Assay Detail
Binding
CHEMBL4328897
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of COX-2 in human whole blood
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Medicinal chemistry of vicinal diaryl scaffold: A mini review.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.02 | 8.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL420987 | — | — | 1 | 8.55 |
| CHEMBL122 | ROFECOXIB | 4.0 | 1 | 6.30 |
| CHEMBL24009 | — | — | 1 | 6.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL420987 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL122 | ROFECOXIB | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL24009 | — | IC50 | = | 620.0 | nM | 6.21 |