Assay Detail
Binding
CHEMBL4329314
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-GR113808 from recombinant human 5-HT4BR expressed in membranes after 60 mins
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel multitarget-directed ligands targeting acetylcholinesterase and σ<sub>1</sub> receptors as lead compounds for treatment of Alzheimer's disease: Synthesis, evaluation, and structural characterization of their complexes with acetylcholinesterase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 7.41 | 8.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL85251 | — | — | 1 | 8.03 |
| CHEMBL3417009 | — | — | 1 | 8.02 |
| CHEMBL4562793 | — | — | 1 | 7.60 |
| CHEMBL4444843 | — | — | 1 | 7.43 |
| CHEMBL4529710 | — | — | 1 | 7.43 |
| CHEMBL4537101 | — | — | 1 | 7.39 |
| CHEMBL4567394 | — | — | 1 | 7.30 |
| CHEMBL4454706 | — | — | 1 | 7.29 |
| CHEMBL4526050 | — | — | 1 | 6.82 |
| CHEMBL4585990 | — | — | 1 | 6.77 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | - |
| CHEMBL4540355 | — | — | 1 | - |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | - |
| CHEMBL4559904 | — | — | 1 | - |
| CHEMBL4541090 | — | — | 1 | - |
| CHEMBL4583738 | — | — | 1 | - |
| CHEMBL4578844 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL85251 | — | Ki | = | 9.33 | nM | 8.03 |
| CHEMBL3417009 | — | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL4562793 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL4444843 | — | Ki | = | 37.5 | nM | 7.43 |
| CHEMBL4529710 | — | Ki | = | 37.5 | nM | 7.43 |
| CHEMBL4537101 | — | Ki | = | 40.9 | nM | 7.39 |
| CHEMBL4567394 | — | Ki | = | 49.6 | nM | 7.30 |
| CHEMBL4454706 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL4526050 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL4585990 | — | Ki | = | 169.0 | nM | 6.77 |
| CHEMBL54 | HALOPERIDOL | Ki | - | — | - | |
| CHEMBL4540355 | — | Ki | - | — | - | |
| CHEMBL502 | DONEPEZIL | Ki | - | — | - | |
| CHEMBL4559904 | — | Ki | - | — | - | |
| CHEMBL4541090 | — | Ki | - | — | - | |
| CHEMBL4583738 | — | Ki | - | — | - | |
| CHEMBL4578844 | — | Ki | - | — | - |