Assay Detail
Binding
CHEMBL4329364
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Inhibition of recombinant C-terminal His-tagged human HDAC11 (1 to 347 residues) expressed in Baculovirus infected insect cells using RHKK-Ac as substrate by fluorimetric assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Highly fluorescent and HDAC6 selective scriptaid analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.38 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 7.82 |
| CHEMBL4475116 | — | — | 1 | 7.10 |
| CHEMBL4532304 | — | — | 1 | 6.82 |
| CHEMBL4526647 | — | — | 1 | 6.72 |
| CHEMBL4461622 | — | — | 1 | 6.68 |
| CHEMBL4160632 | — | — | 1 | 6.54 |
| CHEMBL96051 | SCRIPTAID | — | 1 | 6.44 |
| CHEMBL4465218 | — | — | 1 | 5.99 |
| CHEMBL4567832 | — | — | 1 | 5.91 |
| CHEMBL4476425 | — | — | 1 | 5.09 |
| CHEMBL330201 | — | — | 1 | 5.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4475116 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4532304 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4526647 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4461622 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4160632 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL96051 | SCRIPTAID | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4465218 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL4567832 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL4476425 | — | IC50 | = | 8120.0 | nM | 5.09 |
| CHEMBL330201 | — | IC50 | = | 9350.0 | nM | 5.03 |