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Assay Detail

CHEMBL4329405

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of IDO1 (unknown origin) using L-tryptophan as substrate by spectrophotometric method
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Indoleamine 2,3-dioxygenase 1 (CHEMBL4685)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Diaryl hydroxylamines as pan or dual inhibitors of indoleamine 2,3-dioxygenase-1, indoleamine 2,3-dioxygenase-2 and tryptophan dioxygenase.
Winters M, DuHadaway JB, Pham KN, Lewis-Ballester A, Badir S, Wai J, Sheikh E, Yeh SR, Prendergast GC, Muller AJ, Malachowski WP.
Eur J Med Chem (2019) 162 : 455 -464
PubMed 30469041 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 5.23 6.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4517541 1 6.00
CHEMBL4473408 1 5.70
CHEMBL4561507 1 5.70
CHEMBL4440040 1 5.52
CHEMBL4590292 1 5.52
CHEMBL4578334 1 5.40
CHEMBL4582341 1 5.40
CHEMBL4524223 1 5.30
CHEMBL4544607 1 5.30
CHEMBL4558294 1 5.22
CHEMBL4443640 1 5.16
CHEMBL4585829 1 5.16
CHEMBL4571508 1 5.10
CHEMBL4468826 1 5.10
CHEMBL4516705 1 5.05
CHEMBL4446245 1 4.92
CHEMBL4455554 1 4.80
CHEMBL4451390 1 4.77
CHEMBL4539097 1 4.75
CHEMBL4435742 1 4.64

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4517541 IC50 = 1000.0 nM 6.00
CHEMBL4473408 IC50 = 2000.0 nM 5.70
CHEMBL4561507 IC50 = 2000.0 nM 5.70
CHEMBL4440040 IC50 = 3000.0 nM 5.52
CHEMBL4590292 IC50 = 3000.0 nM 5.52
CHEMBL4578334 IC50 = 4000.0 nM 5.40
CHEMBL4582341 IC50 = 4000.0 nM 5.40
CHEMBL4524223 IC50 = 5000.0 nM 5.30
CHEMBL4544607 IC50 = 5000.0 nM 5.30
CHEMBL4558294 IC50 = 6000.0 nM 5.22
CHEMBL4443640 IC50 = 7000.0 nM 5.16
CHEMBL4585829 IC50 = 7000.0 nM 5.16
CHEMBL4571508 IC50 = 8000.0 nM 5.10
CHEMBL4468826 IC50 = 8000.0 nM 5.10
CHEMBL4516705 IC50 = 9000.0 nM 5.05
CHEMBL4446245 IC50 = 12000.0 nM 4.92
CHEMBL4455554 IC50 = 16000.0 nM 4.80
CHEMBL4451390 IC50 = 17000.0 nM 4.77
CHEMBL4539097 IC50 = 18000.0 nM 4.75
CHEMBL4435742 IC50 = 23000.0 nM 4.64