Assay Detail
Binding
CHEMBL4329645
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Inhibition of PLD1 (unknown origin)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Isoform selective PLD inhibition by novel, chiral 2,8-diazaspiro[4.5]decan-1-one derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.97 | 8.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL524182 | — | — | 1 | 8.43 |
| CHEMBL4446255 | — | — | 1 | 8.22 |
| CHEMBL245621 | HALOPEMIDE | 2.0 | 1 | 7.68 |
| CHEMBL1254577 | — | — | 1 | 5.82 |
| CHEMBL1907089 | — | — | 1 | 4.70 |
| CHEMBL3580438 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL524182 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL4446255 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL245621 | HALOPEMIDE | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL1254577 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1907089 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL3580438 | — | IC50 | > | 30000.0 | nM | - |