Assay Detail
Binding
CHEMBL4329646
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Inhibition of PLD2 (unknown origin)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Isoform selective PLD inhibition by novel, chiral 2,8-diazaspiro[4.5]decan-1-one derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.67 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4446255 | — | — | 1 | 7.70 |
| CHEMBL1254577 | — | — | 1 | 7.70 |
| CHEMBL245621 | HALOPEMIDE | 2.0 | 1 | 6.52 |
| CHEMBL1907089 | — | — | 1 | 6.45 |
| CHEMBL3580438 | — | — | 1 | 6.44 |
| CHEMBL524182 | — | — | 1 | 5.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4446255 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1254577 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL245621 | HALOPEMIDE | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL1907089 | — | IC50 | = | 355.0 | nM | 6.45 |
| CHEMBL3580438 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL524182 | — | IC50 | = | 6400.0 | nM | 5.19 |