Assay Detail
Binding
CHEMBL4329649
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Inhibition of PLD1 in human Calu1 cells
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Isoform selective PLD inhibition by novel, chiral 2,8-diazaspiro[4.5]decan-1-one derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.58 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4453586 | — | — | 1 | 9.00 |
| CHEMBL4514153 | — | — | 1 | 7.80 |
| CHEMBL4448918 | — | — | 1 | 7.80 |
| CHEMBL4475943 | — | — | 1 | 7.68 |
| CHEMBL4570440 | — | — | 1 | 7.60 |
| CHEMBL3902347 | — | — | 1 | 6.70 |
| CHEMBL4581260 | — | — | 1 | 6.60 |
| CHEMBL4436548 | — | — | 1 | 6.50 |
| CHEMBL4591820 | — | — | 1 | 6.50 |
| CHEMBL4594070 | — | — | 1 | 6.09 |
| CHEMBL4515874 | — | — | 1 | 5.92 |
| CHEMBL3923136 | — | — | 1 | 5.87 |
| CHEMBL3943964 | — | — | 1 | 5.77 |
| CHEMBL3983405 | — | — | 1 | 5.26 |
| CHEMBL4584012 | — | — | 1 | 5.19 |
| CHEMBL4109224 | — | — | 1 | 4.92 |
| CHEMBL4109788 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4453586 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4514153 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4448918 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4475943 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4570440 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3902347 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4581260 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4436548 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL4591820 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL4594070 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL4515874 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3923136 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL3943964 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL3983405 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL4584012 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL4109224 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4109788 | — | IC50 | > | 20000.0 | nM | - |