Assay Detail
Binding
CHEMBL4329650
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Inhibition of GFP-fused PLD2 (unknown origin) expressed in HEK293 cells by cellular assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Isoform selective PLD inhibition by novel, chiral 2,8-diazaspiro[4.5]decan-1-one derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.76 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4475943 | — | — | 1 | 8.60 |
| CHEMBL4453586 | — | — | 1 | 7.92 |
| CHEMBL4594070 | — | — | 1 | 7.58 |
| CHEMBL4436548 | — | — | 1 | 7.37 |
| CHEMBL3923136 | — | — | 1 | 7.22 |
| CHEMBL4515874 | — | — | 1 | 7.16 |
| CHEMBL4570440 | — | — | 1 | 6.94 |
| CHEMBL4448918 | — | — | 1 | 6.85 |
| CHEMBL4514153 | — | — | 1 | 6.82 |
| CHEMBL4581260 | — | — | 1 | 6.68 |
| CHEMBL3983405 | — | — | 1 | 6.66 |
| CHEMBL4109224 | — | — | 1 | 6.35 |
| CHEMBL3902347 | — | — | 1 | 6.16 |
| CHEMBL4584012 | — | — | 1 | 6.09 |
| CHEMBL3943964 | — | — | 1 | 5.55 |
| CHEMBL4109788 | — | — | 1 | 5.50 |
| CHEMBL4591820 | — | — | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4475943 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL4453586 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4594070 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4436548 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL3923136 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4515874 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4570440 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL4448918 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4514153 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4581260 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL3983405 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4109224 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL3902347 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4584012 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL3943964 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL4109788 | — | IC50 | = | 3175.0 | nM | 5.50 |
| CHEMBL4591820 | — | IC50 | = | 4000.0 | nM | 5.40 |