Assay Detail
Functional
CHEMBL4329658
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Allosteric modulation of CB1 receptor (unknown origin) assessed as inhibition of calcium mobilization by FLIPR assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Allosteric CB<sub>1</sub> Receptor Modulators for the Treatment of CB<sub>1</sub> Related Diseases and Conditions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.50 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4096928 | — | — | 1 | 7.75 |
| CHEMBL4067016 | — | — | 1 | 7.66 |
| CHEMBL4078901 | — | — | 1 | 7.64 |
| CHEMBL4077975 | — | — | 1 | 7.57 |
| CHEMBL4070648 | — | — | 1 | 7.50 |
| CHEMBL3341861 | — | — | 1 | 7.48 |
| CHEMBL4462132 | — | — | 1 | 7.46 |
| CHEMBL4459402 | — | — | 1 | 7.44 |
| CHEMBL4513876 | — | — | 1 | 7.40 |
| CHEMBL4584264 | — | — | 1 | 7.39 |
| CHEMBL4443345 | — | — | 1 | 7.38 |
| CHEMBL4089126 | — | — | 1 | 7.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4096928 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4067016 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4078901 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4077975 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4070648 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL3341861 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL4462132 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4459402 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL4513876 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4584264 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL4443345 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL4089126 | — | IC50 | = | 47.0 | nM | 7.33 |