Assay Detail
Binding
CHEMBL4329882
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human full length GST-tagged BRAF expressed in baculovirus expression system
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase B-raf (CHEMBL5145) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Privileged Structures and Polypharmacology within and between Protein Families.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.02 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2028663 | DABRAFENIB | 4.0 | 1 | 8.30 |
| CHEMBL3125890 | — | — | 1 | 8.10 |
| CHEMBL1229517 | VEMURAFENIB | 4.0 | 1 | 7.00 |
| CHEMBL1230020 | PLX-4720 | — | 1 | 6.80 |
| CHEMBL4070633 | — | — | 1 | 6.38 |
| CHEMBL4087666 | — | — | 1 | 5.54 |
| CHEMBL4091953 | — | — | 1 | - |
| CHEMBL525191 | — | — | 1 | - |
| CHEMBL558752 | RAF-265 | 2.0 | 1 | - |
| CHEMBL2144069 | — | — | 1 | - |
| CHEMBL4473676 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2028663 | DABRAFENIB | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3125890 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1229517 | VEMURAFENIB | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1230020 | PLX-4720 | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4070633 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL4087666 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4091953 | — | IC50 | - | — | - | |
| CHEMBL525191 | — | IC50 | - | — | - | |
| CHEMBL558752 | RAF-265 | IC50 | - | — | - | |
| CHEMBL2144069 | — | IC50 | - | — | - | |
| CHEMBL4473676 | — | IC50 | > | 10000.0 | nM | - |