Assay Detail
Binding
CHEMBL4329962
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Inhibition of Plasmodium falciparum K1CB1 DHFR NRNI haplotype C59R/S108N double mutant assessed as reduction in NADPH consumption by spectrophotometric method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Hybrid Inhibitors of Malarial Dihydrofolate Reductase with Dual Binding Modes That Can Forestall Resistance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.92 | 9.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4442735 | — | — | 1 | 9.28 |
| CHEMBL4462726 | — | — | 1 | 8.99 |
| CHEMBL4454693 | — | — | 1 | 8.96 |
| CHEMBL4460601 | — | — | 1 | 8.87 |
| CHEMBL3819601 | — | — | 1 | 8.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4442735 | — | Ki | = | 0.53 | nM | 9.28 |
| CHEMBL4462726 | — | Ki | = | 1.03 | nM | 8.99 |
| CHEMBL4454693 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL4460601 | — | Ki | = | 1.34 | nM | 8.87 |
| CHEMBL3819601 | — | Ki | = | 3.15 | nM | 8.50 |