Assay Detail
ADMET
CHEMBL4329966
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Inhibition of human DHFR assessed as reduction in NADPH consumption by spectrophotometric method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Hybrid Inhibitors of Malarial Dihydrofolate Reductase with Dual Binding Modes That Can Forestall Resistance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.58 | 7.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4462726 | — | — | 1 | 7.74 |
| CHEMBL4454693 | — | — | 1 | 7.70 |
| CHEMBL4442735 | — | — | 1 | 7.65 |
| CHEMBL4460601 | — | — | 1 | 7.47 |
| CHEMBL3819601 | — | — | 1 | 7.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4462726 | — | Ki | = | 18.1 | nM | 7.74 |
| CHEMBL4454693 | — | Ki | = | 20.2 | nM | 7.70 |
| CHEMBL4442735 | — | Ki | = | 22.5 | nM | 7.65 |
| CHEMBL4460601 | — | Ki | = | 33.6 | nM | 7.47 |
| CHEMBL3819601 | — | Ki | = | 47.6 | nM | 7.32 |