Assay Detail
Binding
CHEMBL4329973
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Inhibition of Plasmodium falciparum V1/S DHFR IRNL haplotype N51I/C59R/S108N/I164L quadruple mutant
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Hybrid Inhibitors of Malarial Dihydrofolate Reductase with Dual Binding Modes That Can Forestall Resistance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.71 | 8.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL278847 | — | — | 1 | 8.48 |
| CHEMBL3819601 | — | — | 1 | 8.25 |
| CHEMBL36 | PYRIMETHAMINE | 4.0 | 1 | 6.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL278847 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL3819601 | — | Ki | = | 5.59 | nM | 8.25 |
| CHEMBL36 | PYRIMETHAMINE | Ki | = | 390.0 | nM | 6.41 |