Assay Detail
Functional
CHEMBL4329976
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Antiplasmodial activity against Plasmodium falciparum K1CB1 harboring DHFR NRNI haplotype C59R/S108N double mutant infected in human erythrocytes by microdilution radioisotope method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Hybrid Inhibitors of Malarial Dihydrofolate Reductase with Dual Binding Modes That Can Forestall Resistance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.15 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4442735 | — | — | 1 | 6.66 |
| CHEMBL4460601 | — | — | 1 | 6.48 |
| CHEMBL4454693 | — | — | 1 | 5.74 |
| CHEMBL3819601 | — | — | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4442735 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4460601 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL4454693 | — | IC50 | = | 1840.0 | nM | 5.74 |
| CHEMBL3819601 | — | IC50 | = | 1920.0 | nM | 5.72 |