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Assay Detail

CHEMBL4330004

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human beta-N-acetylhexosaminidase using p-nitrophenyl glycoside as substrate by spectrometric method
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Protein O-GlcNAcase (CHEMBL5921)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Modification of the Thioglycosyl-Naphthalimides as Potent and Selective Human O-GlcNAcase Inhibitors.
Shen S, Dong L, Chen W, Zeng X, Lu H, Yang Q, Zhang J.
ACS Med Chem Lett (2018) 9 : 1241 -1246
PubMed 30613333 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 5.50 5.50

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2333316 1 5.50

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2333316 Ki = 3200.0 nM 5.50