Assay Detail
Binding
CHEMBL4330016
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Inhibition of KLK4 (unknown origin) expressed in sf9 cells using Ac-FVQR-pNA as substrate preincubated for 30 mins followed by substrate addition and measured for 7 mins by spectrophotometric method
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potent, Selective, and Cell-Penetrating Inhibitors of Kallikrein-Related Peptidase 4 Based on the Cyclic Peptide MCoTI-II.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 9.31 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4564063 | — | — | 1 | 10.00 |
| CHEMBL4543437 | — | — | 1 | 9.89 |
| CHEMBL4566258 | — | — | 1 | 9.52 |
| CHEMBL4531700 | — | — | 1 | 9.36 |
| CHEMBL4452574 | — | — | 1 | 8.89 |
| CHEMBL4530379 | — | — | 1 | 8.80 |
| CHEMBL4443340 | — | — | 1 | 8.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4564063 | — | Ki | = | 0.1 | nM | 10.00 |
| CHEMBL4543437 | — | Ki | = | 0.13 | nM | 9.89 |
| CHEMBL4566258 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL4531700 | — | Ki | = | 0.44 | nM | 9.36 |
| CHEMBL4452574 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL4530379 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL4443340 | — | Ki | = | 1.8 | nM | 8.74 |