Assay Detail
Binding
CHEMBL4330192
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Inhibition of TRKB (unknown origin)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Insights into Current Tropomyosin Receptor Kinase (TRK) Inhibitors: Development and Clinical Application.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.34 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 8.40 |
| CHEMBL3545365 | ALTIRATINIB | 2.0 | 1 | 8.34 |
| CHEMBL3989926 | SITRAVATINIB | 3.0 | 1 | 8.05 |
| CHEMBL4469569 | — | — | 1 | 4.57 |
| CHEMBL4468886 | — | — | 1 | - |
| CHEMBL2172308 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL575448 | BMS-754807 | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3545365 | ALTIRATINIB | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL3989926 | SITRAVATINIB | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4469569 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL4468886 | — | IC50 | > | 81000.0 | nM | - |
| CHEMBL2172308 | — | IC50 | < | 3.0 | nM | - |