Assay Detail
Toxicity
CHEMBL4330290
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Mitochondrial toxicity in human OCI-AML2 cells assessed as reduction in oxidative phosphorylation-based viability after 72 hrs by CellTiterGlo assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | OCI-AML2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and Cytotoxic and Antiviral Profiling of Pyrrolo- and Furo-Fused 7-Deazapurine Ribonucleosides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.66 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4567695 | — | — | 1 | 6.80 |
| CHEMBL4591383 | — | — | 1 | 6.72 |
| CHEMBL4585910 | — | — | 1 | 6.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4567695 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4591383 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4585910 | — | IC50 | = | 340.0 | nM | 6.47 |