Assay Detail
Functional
CHEMBL4330420
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human A549 cells after 72 hrs by MTT assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of N<sup>1</sup>-(4-((7-(3-(4-ethylpiperazin-1-yl)propoxy)-6-methoxyquinolin-4-yl)oxy)-3,5-difluorophenyl)-N<sup>3</sup>-(2-(2,6-difluorophenyl)-4-oxothiazolidin-3-yl)urea as a multi-tyrosine kinase inhibitor for drug-sensitive and drug-resistant cancers treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.97 | 6.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4587222 | — | — | 1 | 6.46 |
| CHEMBL4472443 | — | — | 1 | 6.42 |
| CHEMBL4566577 | — | — | 1 | 6.40 |
| CHEMBL4472209 | — | — | 1 | 6.35 |
| CHEMBL4451737 | — | — | 1 | 6.29 |
| CHEMBL4460068 | — | — | 1 | 6.25 |
| CHEMBL4160512 | — | — | 1 | 6.16 |
| CHEMBL4437195 | — | — | 1 | 6.16 |
| CHEMBL4470627 | — | — | 1 | 6.08 |
| CHEMBL4462007 | — | — | 1 | 6.06 |
| CHEMBL4586642 | — | — | 1 | 6.02 |
| CHEMBL4552334 | — | — | 1 | 6.01 |
| CHEMBL4460407 | — | — | 1 | 5.86 |
| CHEMBL4462008 | — | — | 1 | 5.84 |
| CHEMBL4584914 | — | — | 1 | 5.82 |
| CHEMBL4587072 | — | — | 1 | 5.79 |
| CHEMBL4522971 | — | — | 1 | 5.71 |
| CHEMBL4563995 | — | — | 1 | 5.63 |
| CHEMBL4468182 | — | — | 1 | 5.62 |
| CHEMBL4587618 | — | — | 1 | 5.44 |
| CHEMBL2105717 | CABOZANTINIB | 4.0 | 1 | 5.02 |
| CHEMBL4446714 | — | — | 1 | - |
| CHEMBL4483794 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4587222 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL4472443 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL4566577 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4472209 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL4451737 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL4460068 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL4160512 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL4437195 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL4470627 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL4462007 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL4586642 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL4552334 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL4460407 | — | IC50 | = | 1390.0 | nM | 5.86 |
| CHEMBL4462008 | — | IC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL4584914 | — | IC50 | = | 1520.0 | nM | 5.82 |
| CHEMBL4587072 | — | IC50 | = | 1630.0 | nM | 5.79 |
| CHEMBL4522971 | — | IC50 | = | 1930.0 | nM | 5.71 |
| CHEMBL4563995 | — | IC50 | = | 2360.0 | nM | 5.63 |
| CHEMBL4468182 | — | IC50 | = | 2380.0 | nM | 5.62 |
| CHEMBL4587618 | — | IC50 | = | 3610.0 | nM | 5.44 |
| CHEMBL2105717 | CABOZANTINIB | IC50 | = | 9520.0 | nM | 5.02 |
| CHEMBL4446714 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4483794 | — | IC50 | > | 20000.0 | nM | - |