Assay Detail
Functional
CHEMBL4330421
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Antiproliferative activity against human HT-29 cells after 72 hrs by MTT assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of N<sup>1</sup>-(4-((7-(3-(4-ethylpiperazin-1-yl)propoxy)-6-methoxyquinolin-4-yl)oxy)-3,5-difluorophenyl)-N<sup>3</sup>-(2-(2,6-difluorophenyl)-4-oxothiazolidin-3-yl)urea as a multi-tyrosine kinase inhibitor for drug-sensitive and drug-resistant cancers treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 6.31 | 7.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4587222 | — | — | 1 | 7.14 |
| CHEMBL4472209 | — | — | 1 | 7.04 |
| CHEMBL4451737 | — | — | 1 | 6.82 |
| CHEMBL4552334 | — | — | 1 | 6.66 |
| CHEMBL4460068 | — | — | 1 | 6.64 |
| CHEMBL4566577 | — | — | 1 | 6.57 |
| CHEMBL4472443 | — | — | 1 | 6.55 |
| CHEMBL4584914 | — | — | 1 | 6.46 |
| CHEMBL4160512 | — | — | 1 | 6.46 |
| CHEMBL4437195 | — | — | 1 | 6.39 |
| CHEMBL4587072 | — | — | 1 | 6.39 |
| CHEMBL4522971 | — | — | 1 | 6.33 |
| CHEMBL4462007 | — | — | 1 | 6.32 |
| CHEMBL4468182 | — | — | 1 | 6.31 |
| CHEMBL4586642 | — | — | 1 | 6.20 |
| CHEMBL4470627 | — | — | 1 | 6.17 |
| CHEMBL4587618 | — | — | 1 | 6.10 |
| CHEMBL4460407 | — | — | 1 | 6.08 |
| CHEMBL4462008 | — | — | 1 | 6.02 |
| CHEMBL4446714 | — | — | 1 | 5.88 |
| CHEMBL4483794 | — | — | 1 | 5.85 |
| CHEMBL4563995 | — | — | 1 | 5.73 |
| CHEMBL2105717 | CABOZANTINIB | 4.0 | 1 | 4.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4587222 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL4472209 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL4451737 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4552334 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4460068 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4566577 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL4472443 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL4584914 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL4160512 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL4437195 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL4587072 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL4522971 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL4462007 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL4468182 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL4586642 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL4470627 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL4587618 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL4460407 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL4462008 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL4446714 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL4483794 | — | IC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL4563995 | — | IC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL2105717 | CABOZANTINIB | IC50 | = | 11500.0 | nM | 4.94 |