Assay Detail
Functional
CHEMBL4330424
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Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of N<sup>1</sup>-(4-((7-(3-(4-ethylpiperazin-1-yl)propoxy)-6-methoxyquinolin-4-yl)oxy)-3,5-difluorophenyl)-N<sup>3</sup>-(2-(2,6-difluorophenyl)-4-oxothiazolidin-3-yl)urea as a multi-tyrosine kinase inhibitor for drug-sensitive and drug-resistant cancers treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.56 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4587222 | — | — | 1 | 5.82 |
| CHEMBL4472209 | — | — | 1 | 5.80 |
| CHEMBL2105717 | CABOZANTINIB | 4.0 | 1 | 5.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4587222 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4472209 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL2105717 | CABOZANTINIB | IC50 | = | 8570.0 | nM | 5.07 |