Assay Detail
Functional
CHEMBL4330505
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human 518A2 cells after 72 hrs by MTT assay
40
Total Activities
20
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | 518A2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
New naphthopyran analogues of LY290181 as potential tumor vascular-disrupting agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 20 | - | - |
| IC50 | 20 | 6.56 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4547354 | — | — | 2 | 7.62 |
| CHEMBL4473535 | — | — | 2 | 7.61 |
| CHEMBL4464137 | — | — | 2 | 7.58 |
| CHEMBL321336 | — | — | 2 | 7.45 |
| CHEMBL4469871 | — | — | 2 | 7.43 |
| CHEMBL4471330 | — | — | 2 | 7.35 |
| CHEMBL4436712 | — | — | 2 | 7.22 |
| CHEMBL4435920 | — | — | 2 | 6.84 |
| CHEMBL4586497 | — | — | 2 | 6.65 |
| CHEMBL4586349 | — | — | 2 | 6.64 |
| CHEMBL4442805 | — | — | 2 | 6.37 |
| CHEMBL4436683 | — | — | 2 | 6.30 |
| CHEMBL4558563 | — | — | 2 | 6.12 |
| CHEMBL4567907 | — | — | 2 | 6.03 |
| CHEMBL4459676 | — | — | 2 | 5.87 |
| CHEMBL4585739 | — | — | 2 | 5.78 |
| CHEMBL4441682 | — | — | 2 | 5.70 |
| CHEMBL4536562 | — | — | 2 | 5.15 |
| CHEMBL4451738 | — | — | 2 | 5.00 |
| CHEMBL4475290 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4547354 | — | IC50 | = | 24.1 | nM | 7.62 |
| CHEMBL4473535 | — | IC50 | = | 24.4 | nM | 7.61 |
| CHEMBL4464137 | — | IC50 | = | 26.4 | nM | 7.58 |
| CHEMBL321336 | — | IC50 | = | 35.9 | nM | 7.45 |
| CHEMBL4469871 | — | IC50 | = | 37.1 | nM | 7.43 |
| CHEMBL4471330 | — | IC50 | = | 44.6 | nM | 7.35 |
| CHEMBL4436712 | — | IC50 | = | 60.5 | nM | 7.22 |
| CHEMBL4435920 | — | IC50 | = | 144.0 | nM | 6.84 |
| CHEMBL4586497 | — | IC50 | = | 225.0 | nM | 6.65 |
| CHEMBL4586349 | — | IC50 | = | 229.0 | nM | 6.64 |
| CHEMBL4442805 | — | IC50 | = | 425.0 | nM | 6.37 |
| CHEMBL4436683 | — | IC50 | = | 505.0 | nM | 6.30 |
| CHEMBL4558563 | — | IC50 | = | 753.0 | nM | 6.12 |
| CHEMBL4567907 | — | IC50 | = | 939.0 | nM | 6.03 |
| CHEMBL4459676 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL4585739 | — | IC50 | = | 1660.0 | nM | 5.78 |
| CHEMBL4441682 | — | IC50 | = | 1980.0 | nM | 5.70 |
| CHEMBL4536562 | — | IC50 | = | 7130.0 | nM | 5.15 |
| CHEMBL4451738 | — | IC50 | = | 9910.0 | nM | 5.00 |
| CHEMBL4585739 | — | Activity | - | — | - | |
| CHEMBL4536562 | — | Activity | - | — | - | |
| CHEMBL4442805 | — | Activity | - | — | - | |
| CHEMBL321336 | — | Activity | - | — | - | |
| CHEMBL4586497 | — | Activity | - | — | - | |
| CHEMBL4464137 | — | Activity | - | — | - | |
| CHEMBL4547354 | — | Activity | - | — | - | |
| CHEMBL4475290 | — | Activity | - | — | - | |
| CHEMBL4436712 | — | Activity | - | — | - | |
| CHEMBL4441682 | — | Activity | - | — | - | |
| CHEMBL4435920 | — | Activity | - | — | - | |
| CHEMBL4471330 | — | Activity | - | — | - | |
| CHEMBL4558563 | — | Activity | - | — | - | |
| CHEMBL4473535 | — | Activity | - | — | - | |
| CHEMBL4459676 | — | Activity | - | — | - | |
| CHEMBL4469871 | — | Activity | - | — | - | |
| CHEMBL4586349 | — | Activity | - | — | - | |
| CHEMBL4567907 | — | Activity | - | — | - | |
| CHEMBL4451738 | — | Activity | - | — | - | |
| CHEMBL4436683 | — | Activity | - | — | - | |
| CHEMBL4475290 | — | IC50 | < | 0.1 | nM | - |