Assay Detail
Binding
CHEMBL4331189
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Inhibition of GAC (unknown origin)
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Glutaminase kidney isoform, mitochondrial (CHEMBL2146302) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and development of small molecule modulators targeting glutamine metabolism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.81 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3639788 | TELAGLENASTAT | 2.0 | 1 | 8.30 |
| CHEMBL3669995 | — | — | 1 | 7.24 |
| CHEMBL3670004 | — | — | 1 | 7.10 |
| CHEMBL4555453 | — | — | 1 | 7.00 |
| CHEMBL4588102 | — | — | 1 | 7.00 |
| CHEMBL4452081 | — | — | 1 | 6.00 |
| CHEMBL4548854 | — | — | 1 | 6.00 |
| CHEMBL3664910 | — | — | 1 | 5.85 |
| CHEMBL3680036 | — | — | 1 | - |
| CHEMBL4545450 | — | — | 1 | - |
| CHEMBL4450417 | — | — | 1 | - |
| CHEMBL4466771 | — | — | 1 | - |
| CHEMBL4534887 | — | — | 1 | - |
| CHEMBL4451183 | — | — | 1 | - |
| CHEMBL4436826 | — | — | 1 | - |
| CHEMBL4526782 | — | — | 1 | - |
| CHEMBL4574354 | — | — | 1 | - |
| CHEMBL4435601 | — | — | 1 | - |
| CHEMBL4567806 | — | — | 1 | - |
| CHEMBL4445159 | — | — | 1 | - |
| CHEMBL4438668 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3639788 | TELAGLENASTAT | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3669995 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL3670004 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4555453 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4588102 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4452081 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4548854 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3664910 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL3680036 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4545450 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL4450417 | — | IC50 | < | 100.0 | nM | - |
| CHEMBL4466771 | — | IC50 | < | 100.0 | nM | - |
| CHEMBL4534887 | — | IC50 | < | 100.0 | nM | - |
| CHEMBL4451183 | — | IC50 | < | 100.0 | nM | - |
| CHEMBL4436826 | — | IC50 | < | 100.0 | nM | - |
| CHEMBL4526782 | — | IC50 | < | 100.0 | nM | - |
| CHEMBL4574354 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL4435601 | — | IC50 | < | 100.0 | nM | - |
| CHEMBL4567806 | — | IC50 | < | 100.0 | nM | - |
| CHEMBL4445159 | — | IC50 | < | 100.0 | nM | - |
| CHEMBL4438668 | — | IC50 | < | 100.0 | nM | - |