Assay Detail
Binding
CHEMBL4331289
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Inhibition of human full-length recombinant HDAC1 expressed in baculovirus infected Sf9 insect cells using fluorogenic peptide RHKKAc as substrate after 2 hrs
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Quinazolin-2,4-dione-Based Hydroxamic Acids as Selective Histone Deacetylase-6 Inhibitors for Treatment of Non-Small Cell Lung Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 4.96 | 5.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4457790 | — | — | 1 | 5.18 |
| CHEMBL4437282 | — | — | 1 | 5.13 |
| CHEMBL4513424 | — | — | 1 | 5.10 |
| CHEMBL4441436 | — | — | 1 | 5.08 |
| CHEMBL4462263 | — | — | 1 | 5.04 |
| CHEMBL4579683 | — | — | 1 | 5.03 |
| CHEMBL4565933 | — | — | 1 | 5.02 |
| CHEMBL4554270 | — | — | 1 | 4.98 |
| CHEMBL4453971 | — | — | 1 | 4.97 |
| CHEMBL4517827 | — | — | 1 | 4.96 |
| CHEMBL4550214 | — | — | 1 | 4.95 |
| CHEMBL4438057 | — | — | 1 | 4.95 |
| CHEMBL4537684 | — | — | 1 | 4.92 |
| CHEMBL4564622 | — | — | 1 | 4.90 |
| CHEMBL4442777 | — | — | 1 | 4.88 |
| CHEMBL4470654 | — | — | 1 | 4.87 |
| CHEMBL4474286 | — | — | 1 | 4.84 |
| CHEMBL4464975 | — | — | 1 | 4.72 |
| CHEMBL4552452 | — | — | 1 | 4.64 |
| CHEMBL4473726 | — | — | 1 | - |
| CHEMBL4457073 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4457790 | — | IC50 | = | 6655.0 | nM | 5.18 |
| CHEMBL4437282 | — | IC50 | = | 7374.0 | nM | 5.13 |
| CHEMBL4513424 | — | IC50 | = | 8021.0 | nM | 5.10 |
| CHEMBL4441436 | — | IC50 | = | 8275.0 | nM | 5.08 |
| CHEMBL4462263 | — | IC50 | = | 9080.0 | nM | 5.04 |
| CHEMBL4579683 | — | IC50 | = | 9410.0 | nM | 5.03 |
| CHEMBL4565933 | — | IC50 | = | 9540.0 | nM | 5.02 |
| CHEMBL4554270 | — | IC50 | = | 10430.0 | nM | 4.98 |
| CHEMBL4453971 | — | IC50 | = | 10810.0 | nM | 4.97 |
| CHEMBL4517827 | — | IC50 | = | 10870.0 | nM | 4.96 |
| CHEMBL4550214 | — | IC50 | = | 11160.0 | nM | 4.95 |
| CHEMBL4438057 | — | IC50 | = | 11150.0 | nM | 4.95 |
| CHEMBL4537684 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4564622 | — | IC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL4442777 | — | IC50 | = | 13170.0 | nM | 4.88 |
| CHEMBL4470654 | — | IC50 | = | 13410.0 | nM | 4.87 |
| CHEMBL4474286 | — | IC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL4464975 | — | IC50 | = | 18860.0 | nM | 4.72 |
| CHEMBL4552452 | — | IC50 | = | 22940.0 | nM | 4.64 |
| CHEMBL4473726 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4457073 | — | IC50 | > | 10000.0 | nM | - |