Assay Detail
Binding
CHEMBL4331290
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Inhibition of human full-length recombinant HDAC6 expressed in baculovirus infected Sf9 insect cells using fluorogenic peptide RHKKAc as substrate after 2 hrs
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Quinazolin-2,4-dione-Based Hydroxamic Acids as Selective Histone Deacetylase-6 Inhibitors for Treatment of Non-Small Cell Lung Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 7.38 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4550214 | — | — | 1 | 8.40 |
| CHEMBL4462263 | — | — | 1 | 8.30 |
| CHEMBL4579683 | — | — | 1 | 8.10 |
| CHEMBL4442777 | — | — | 1 | 8.00 |
| CHEMBL4554270 | — | — | 1 | 7.92 |
| CHEMBL4457790 | — | — | 1 | 7.82 |
| CHEMBL4552452 | — | — | 1 | 7.70 |
| CHEMBL4437282 | — | — | 1 | 7.70 |
| CHEMBL4565933 | — | — | 1 | 7.66 |
| CHEMBL4453971 | — | — | 1 | 7.64 |
| CHEMBL4564622 | — | — | 1 | 7.62 |
| CHEMBL4438057 | — | — | 1 | 7.54 |
| CHEMBL4441436 | — | — | 1 | 7.50 |
| CHEMBL4464975 | — | — | 1 | 7.46 |
| CHEMBL4537684 | — | — | 1 | 7.29 |
| CHEMBL4470654 | — | — | 1 | 7.24 |
| CHEMBL4474286 | — | — | 1 | 6.78 |
| CHEMBL4517827 | — | — | 1 | 6.77 |
| CHEMBL4513424 | — | — | 1 | 6.20 |
| CHEMBL4457073 | — | — | 1 | 5.92 |
| CHEMBL4473726 | — | — | 1 | 5.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4550214 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4462263 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4579683 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4442777 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4554270 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4457790 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4552452 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4437282 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4565933 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4453971 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4564622 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4438057 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4441436 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4464975 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4537684 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL4470654 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL4474286 | — | IC50 | = | 168.0 | nM | 6.78 |
| CHEMBL4517827 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4513424 | — | IC50 | = | 636.0 | nM | 6.20 |
| CHEMBL4457073 | — | IC50 | = | 1194.0 | nM | 5.92 |
| CHEMBL4473726 | — | IC50 | = | 4630.0 | nM | 5.33 |