Assay Detail
Binding
CHEMBL4331291
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Inhibition of human full-length recombinant HDAC8 expressed in baculovirus infected Sf9 insect cells using fluorogenic peptide RHKAcKAc as substrate after 2 hrs
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Quinazolin-2,4-dione-Based Hydroxamic Acids as Selective Histone Deacetylase-6 Inhibitors for Treatment of Non-Small Cell Lung Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.11 | 7.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4579683 | — | — | 1 | 7.02 |
| CHEMBL4552452 | — | — | 1 | 7.01 |
| CHEMBL4457790 | — | — | 1 | 6.77 |
| CHEMBL4550214 | — | — | 1 | 6.51 |
| CHEMBL4442777 | — | — | 1 | 6.37 |
| CHEMBL4554270 | — | — | 1 | 6.28 |
| CHEMBL4473726 | — | — | 1 | 6.18 |
| CHEMBL4537684 | — | — | 1 | 6.14 |
| CHEMBL4462263 | — | — | 1 | 6.07 |
| CHEMBL4453971 | — | — | 1 | 5.98 |
| CHEMBL4438057 | — | — | 1 | 5.97 |
| CHEMBL4437282 | — | — | 1 | 5.94 |
| CHEMBL4470654 | — | — | 1 | 5.94 |
| CHEMBL4457073 | — | — | 1 | 5.92 |
| CHEMBL4513424 | — | — | 1 | 5.84 |
| CHEMBL4565933 | — | — | 1 | 5.79 |
| CHEMBL4564622 | — | — | 1 | 5.75 |
| CHEMBL4517827 | — | — | 1 | 5.60 |
| CHEMBL4441436 | — | — | 1 | 5.56 |
| CHEMBL4474286 | — | — | 1 | 5.51 |
| CHEMBL4464975 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4579683 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL4552452 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL4457790 | — | IC50 | = | 169.0 | nM | 6.77 |
| CHEMBL4550214 | — | IC50 | = | 309.0 | nM | 6.51 |
| CHEMBL4442777 | — | IC50 | = | 429.0 | nM | 6.37 |
| CHEMBL4554270 | — | IC50 | = | 525.0 | nM | 6.28 |
| CHEMBL4473726 | — | IC50 | = | 653.0 | nM | 6.18 |
| CHEMBL4537684 | — | IC50 | = | 731.0 | nM | 6.14 |
| CHEMBL4462263 | — | IC50 | = | 845.0 | nM | 6.07 |
| CHEMBL4453971 | — | IC50 | = | 1049.0 | nM | 5.98 |
| CHEMBL4438057 | — | IC50 | = | 1068.0 | nM | 5.97 |
| CHEMBL4437282 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL4470654 | — | IC50 | = | 1155.0 | nM | 5.94 |
| CHEMBL4457073 | — | IC50 | = | 1191.0 | nM | 5.92 |
| CHEMBL4513424 | — | IC50 | = | 1442.0 | nM | 5.84 |
| CHEMBL4565933 | — | IC50 | = | 1640.0 | nM | 5.79 |
| CHEMBL4564622 | — | IC50 | = | 1760.0 | nM | 5.75 |
| CHEMBL4517827 | — | IC50 | = | 2521.0 | nM | 5.60 |
| CHEMBL4441436 | — | IC50 | = | 2751.0 | nM | 5.56 |
| CHEMBL4474286 | — | IC50 | = | 3060.0 | nM | 5.51 |
| CHEMBL4464975 | — | IC50 | - | — | - |