Assay Detail
Binding
CHEMBL4331292
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Inhibition of human full-length recombinant HDAC11 expressed in baculovirus infected Sf9 insect cells using fluorogenic peptide RHKKAc as substrate after 2 hrs
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Quinazolin-2,4-dione-Based Hydroxamic Acids as Selective Histone Deacetylase-6 Inhibitors for Treatment of Non-Small Cell Lung Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 4.85 | 5.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4441436 | — | — | 1 | 5.26 |
| CHEMBL4457790 | — | — | 1 | 5.25 |
| CHEMBL4513424 | — | — | 1 | 5.13 |
| CHEMBL4474286 | — | — | 1 | 4.98 |
| CHEMBL4442777 | — | — | 1 | 4.97 |
| CHEMBL4462263 | — | — | 1 | 4.95 |
| CHEMBL4550214 | — | — | 1 | 4.86 |
| CHEMBL4437282 | — | — | 1 | 4.86 |
| CHEMBL4453971 | — | — | 1 | 4.83 |
| CHEMBL4579683 | — | — | 1 | 4.81 |
| CHEMBL4470654 | — | — | 1 | 4.78 |
| CHEMBL4552452 | — | — | 1 | 4.70 |
| CHEMBL4438057 | — | — | 1 | 4.60 |
| CHEMBL4554270 | — | — | 1 | 4.46 |
| CHEMBL4517827 | — | — | 1 | 4.28 |
| CHEMBL4464975 | — | — | 1 | - |
| CHEMBL4537684 | — | — | 1 | - |
| CHEMBL4564622 | — | — | 1 | - |
| CHEMBL4473726 | — | — | 1 | - |
| CHEMBL4457073 | — | — | 1 | - |
| CHEMBL4565933 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4441436 | — | IC50 | = | 5501.0 | nM | 5.26 |
| CHEMBL4457790 | — | IC50 | = | 5686.0 | nM | 5.25 |
| CHEMBL4513424 | — | IC50 | = | 7392.0 | nM | 5.13 |
| CHEMBL4474286 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL4442777 | — | IC50 | = | 10660.0 | nM | 4.97 |
| CHEMBL4462263 | — | IC50 | = | 11290.0 | nM | 4.95 |
| CHEMBL4550214 | — | IC50 | = | 13900.0 | nM | 4.86 |
| CHEMBL4437282 | — | IC50 | = | 13850.0 | nM | 4.86 |
| CHEMBL4453971 | — | IC50 | = | 14730.0 | nM | 4.83 |
| CHEMBL4579683 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL4470654 | — | IC50 | = | 16740.0 | nM | 4.78 |
| CHEMBL4552452 | — | IC50 | = | 19800.0 | nM | 4.70 |
| CHEMBL4438057 | — | IC50 | = | 25050.0 | nM | 4.60 |
| CHEMBL4554270 | — | IC50 | = | 34370.0 | nM | 4.46 |
| CHEMBL4517827 | — | IC50 | = | 52050.0 | nM | 4.28 |
| CHEMBL4464975 | — | IC50 | - | — | - | |
| CHEMBL4537684 | — | IC50 | - | — | - | |
| CHEMBL4564622 | — | IC50 | - | — | - | |
| CHEMBL4473726 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4457073 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4565933 | — | IC50 | - | — | - |