Assay Detail
Binding
CHEMBL4331295
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human full-length recombinant HDAC6 expressed in baculovirus infected Sf9 insect cells using Boc-Lys (Ac)-AMC as substrate preincubated for 10 mins followed by substrate addition and measured after 30 mins by fluorescence assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Quinazolin-2,4-dione-Based Hydroxamic Acids as Selective Histone Deacetylase-6 Inhibitors for Treatment of Non-Small Cell Lung Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 8.52 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4554270 | — | — | 1 | 8.68 |
| CHEMBL2018302 | TUBASTATIN A | — | 1 | 8.46 |
| CHEMBL4438057 | — | — | 1 | 8.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4554270 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL2018302 | TUBASTATIN A | Ki | = | 3.43 | nM | 8.46 |
| CHEMBL4438057 | — | Ki | = | 3.89 | nM | 8.41 |