Assay Detail
Functional
CHEMBL4331302
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Cytotoxicity against human A549 cells after 72 hrs by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Quinazolin-2,4-dione-Based Hydroxamic Acids as Selective Histone Deacetylase-6 Inhibitors for Treatment of Non-Small Cell Lung Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.22 | 5.65 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.65 |
| CHEMBL4438057 | — | — | 1 | 5.55 |
| CHEMBL4453971 | — | — | 1 | 5.44 |
| CHEMBL4579683 | — | — | 1 | 5.41 |
| CHEMBL4564622 | — | — | 1 | 5.22 |
| CHEMBL2364628 | RICOLINOSTAT | 2.0 | 1 | 5.11 |
| CHEMBL4550214 | — | — | 1 | 5.10 |
| CHEMBL4554270 | — | — | 1 | 4.93 |
| CHEMBL4470654 | — | — | 1 | 4.91 |
| CHEMBL4552452 | — | — | 1 | 4.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | IC50 | = | 2240.0 | nM | 5.65 |
| CHEMBL4438057 | — | IC50 | = | 2840.0 | nM | 5.55 |
| CHEMBL4453971 | — | IC50 | = | 3650.0 | nM | 5.44 |
| CHEMBL4579683 | — | IC50 | = | 3920.0 | nM | 5.41 |
| CHEMBL4564622 | — | IC50 | = | 6030.0 | nM | 5.22 |
| CHEMBL2364628 | RICOLINOSTAT | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL4550214 | — | IC50 | = | 7870.0 | nM | 5.10 |
| CHEMBL4554270 | — | IC50 | = | 11780.0 | nM | 4.93 |
| CHEMBL4470654 | — | IC50 | = | 12190.0 | nM | 4.91 |
| CHEMBL4552452 | — | IC50 | = | 13500.0 | nM | 4.87 |