Assay Detail
Binding
CHEMBL4331381
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Inhibition of sheep brain tubulin polymerization by DAPI-fluorescence based fluorimetry
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Ovis aries |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
1,1-Diheterocyclic Ethylenes Derived from Quinaldine and Carbazole as New Tubulin-Polymerization Inhibitors: Synthesis, Metabolism, and Biological Evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.39 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4474171 | — | — | 1 | 5.72 |
| CHEMBL4584494 | — | — | 1 | 5.70 |
| CHEMBL498271 | — | — | 1 | 5.68 |
| CHEMBL4476716 | — | — | 1 | 5.68 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 5.66 |
| CHEMBL4565057 | — | — | 1 | 5.58 |
| CHEMBL4445657 | — | — | 1 | 5.52 |
| CHEMBL4538738 | — | — | 1 | 5.44 |
| CHEMBL4551060 | — | — | 1 | 5.43 |
| CHEMBL4517935 | — | — | 1 | 5.36 |
| CHEMBL4573850 | — | — | 1 | 5.28 |
| CHEMBL4574710 | — | — | 1 | 5.21 |
| CHEMBL4570016 | — | — | 1 | 5.14 |
| CHEMBL4464329 | — | — | 1 | 4.81 |
| CHEMBL4516996 | — | — | 1 | 4.71 |
| CHEMBL4580553 | — | — | 1 | - |
| CHEMBL4591900 | — | — | 1 | - |
| CHEMBL4568448 | — | — | 1 | - |
| CHEMBL4529564 | — | — | 1 | - |
| CHEMBL4572347 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4474171 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4584494 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL498271 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4476716 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4565057 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4445657 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4538738 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL4551060 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL4517935 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL4573850 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL4574710 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL4570016 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL4464329 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL4516996 | — | IC50 | = | 19500.0 | nM | 4.71 |
| CHEMBL4580553 | — | IC50 | - | — | - | |
| CHEMBL4591900 | — | IC50 | - | — | - | |
| CHEMBL4568448 | — | IC50 | - | — | - | |
| CHEMBL4529564 | — | IC50 | - | — | - | |
| CHEMBL4572347 | — | IC50 | - | — | - |