Assay Detail
Binding
CHEMBL4331498
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of BRAF (unknown origin)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase B-raf (CHEMBL5145) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of potent Pan-Raf inhibitors with increased solubility to overcome drug resistance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.91 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3577124 | LY-3009120 | 1.0 | 1 | 8.82 |
| CHEMBL1229517 | VEMURAFENIB | 4.0 | 1 | 8.16 |
| CHEMBL4438236 | — | — | 1 | 8.03 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 7.65 |
| CHEMBL4436132 | — | — | 1 | 7.40 |
| CHEMBL4586402 | — | — | 1 | 7.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3577124 | LY-3009120 | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL1229517 | VEMURAFENIB | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL4438236 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 22.6 | nM | 7.65 |
| CHEMBL4436132 | — | IC50 | = | 39.6 | nM | 7.40 |
| CHEMBL4586402 | — | IC50 | = | 43.1 | nM | 7.37 |