Assay Detail
Binding
CHEMBL4331499
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of cRAF (unknown origin)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
RAF proto-oncogene serine/threonine-protein kinase (CHEMBL1906) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of potent Pan-Raf inhibitors with increased solubility to overcome drug resistance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.88 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4438236 | — | — | 1 | 8.57 |
| CHEMBL3577124 | LY-3009120 | 1.0 | 1 | 8.42 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 8.21 |
| CHEMBL4436132 | — | — | 1 | 7.70 |
| CHEMBL4586402 | — | — | 1 | 7.50 |
| CHEMBL1229517 | VEMURAFENIB | 4.0 | 1 | 6.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4438236 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL3577124 | LY-3009120 | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL4436132 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4586402 | — | IC50 | = | 31.7 | nM | 7.50 |
| CHEMBL1229517 | VEMURAFENIB | IC50 | = | 135.0 | nM | 6.87 |