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Assay Detail

CHEMBL4331525

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Anti-plasmodial activity against synchronized ring stage Plasmodium falciparum 3D7 infected in human erythrocytes assessed as reduction in parasitemia after 48 hrs by Sybr Green I dye-based flow cytometric analysis
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Hydroxyazole scaffold-based Plasmodium falciparum dihydroorotate dehydrogenase inhibitors: Synthesis, biological evaluation and X-ray structural studies.
Pippione AC, Sainas S, Goyal P, Fritzson I, Cassiano GC, Giraudo A, Giorgis M, Tavella TA, Bagnati R, Rolando B, Caing-Carlsson R, Costa FTM, Andrade CH, Al-Karadaghi S, Boschi D, Friemann R, Lolli ML.
Eur J Med Chem (2019) 163 : 266 -280
PubMed 30529545 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 18 4.47 4.57

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4539458 1 4.57
CHEMBL4517934 1 4.45
CHEMBL4458056 1 4.39
CHEMBL4568957 1 -
CHEMBL4569109 1 -
CHEMBL4544292 1 -
CHEMBL4440085 1 -
CHEMBL4514633 1 -
CHEMBL4451149 1 -
CHEMBL4449622 1 -
CHEMBL4457827 1 -
CHEMBL4526067 1 -
CHEMBL4437588 1 -
CHEMBL4436588 1 -
CHEMBL4464362 1 -
CHEMBL3218518 1 -
CHEMBL475813 1 -
CHEMBL4514989 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4539458 EC50 = 26700.0 nM 4.57
CHEMBL4517934 EC50 = 35900.0 nM 4.45
CHEMBL4458056 EC50 = 40700.0 nM 4.39
CHEMBL4568957 EC50 - -
CHEMBL4569109 EC50 - -
CHEMBL4544292 EC50 - -
CHEMBL4440085 EC50 - -
CHEMBL4514633 EC50 - -
CHEMBL4451149 EC50 - -
CHEMBL4449622 EC50 - -
CHEMBL4457827 EC50 - -
CHEMBL4526067 EC50 - -
CHEMBL4437588 EC50 - -
CHEMBL4436588 EC50 - -
CHEMBL4464362 EC50 - -
CHEMBL3218518 EC50 - -
CHEMBL475813 EC50 - -
CHEMBL4514989 EC50 - -