Assay Detail
Binding
CHEMBL4331570
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Inhibition of human MAO-A preincubated for 15 mins followed by p-tyramine substrate addition and measured after 20 mins by Amplex red reagent based fluorescence assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of isoprenylation-resveratrol dimer derivatives against Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.04 | 5.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4552841 | — | — | 1 | 5.58 |
| CHEMBL92401 | IPRONIAZID | 2.0 | 1 | 5.16 |
| CHEMBL4439631 | — | — | 1 | 5.09 |
| CHEMBL518935 | — | — | 1 | 5.05 |
| CHEMBL4586379 | — | — | 1 | 4.97 |
| CHEMBL2230263 | ARACHIDIN-2 | — | 1 | 4.95 |
| CHEMBL165 | RESVERATROL | 3.0 | 1 | 4.80 |
| CHEMBL4591420 | — | — | 1 | 4.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4552841 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL92401 | IPRONIAZID | IC50 | = | 6850.0 | nM | 5.16 |
| CHEMBL4439631 | — | IC50 | = | 8120.0 | nM | 5.09 |
| CHEMBL518935 | — | IC50 | = | 8930.0 | nM | 5.05 |
| CHEMBL4586379 | — | IC50 | = | 10610.0 | nM | 4.97 |
| CHEMBL2230263 | ARACHIDIN-2 | IC50 | = | 11250.0 | nM | 4.95 |
| CHEMBL165 | RESVERATROL | IC50 | = | 15700.0 | nM | 4.80 |
| CHEMBL4591420 | — | IC50 | = | 18940.0 | nM | 4.72 |