Assay Detail
Binding
CHEMBL4331687
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Displacement of F-NEO from human mitochondrial rRNA-A site C1410U mutant after 10 to 20 mins by fluorescence assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis, antimicrobial activity, attenuation of aminoglycoside resistance in MRSA, and ribosomal A-site binding of pyrene-neomycin conjugates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.79 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4442608 | — | — | 1 | 7.16 |
| CHEMBL4536151 | — | — | 1 | 6.90 |
| CHEMBL4457923 | — | — | 1 | 6.83 |
| CHEMBL445770 | — | — | 1 | 6.83 |
| CHEMBL4459175 | — | — | 1 | 6.75 |
| CHEMBL4438817 | — | — | 1 | 6.56 |
| CHEMBL4527321 | — | — | 1 | 6.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4442608 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4536151 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL4457923 | — | IC50 | = | 147.0 | nM | 6.83 |
| CHEMBL445770 | — | IC50 | = | 149.0 | nM | 6.83 |
| CHEMBL4459175 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4438817 | — | IC50 | = | 274.0 | nM | 6.56 |
| CHEMBL4527321 | — | IC50 | = | 332.0 | nM | 6.48 |