Assay Detail
Binding
CHEMBL4331731
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Binding affinity to rRNA-A site in Escherichia coli S30 extract assessed as inhibition of protein translation after 20 mins
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis, antimicrobial activity, attenuation of aminoglycoside resistance in MRSA, and ribosomal A-site binding of pyrene-neomycin conjugates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.29 | 6.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4459175 | — | — | 1 | 6.67 |
| CHEMBL4442608 | — | — | 1 | 6.57 |
| CHEMBL4536151 | — | — | 1 | 6.03 |
| CHEMBL4438817 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4459175 | — | IC50 | = | 212.6 | nM | 6.67 |
| CHEMBL4442608 | — | IC50 | = | 268.8 | nM | 6.57 |
| CHEMBL4536151 | — | IC50 | = | 927.0 | nM | 6.03 |
| CHEMBL4438817 | — | IC50 | = | 1280.0 | nM | 5.89 |