Assay Detail
Binding
CHEMBL4331737
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MNK2 (unknown origin) expressed in HEK293 cells assessed as decrease in eIF4E phosphorylation at Ser209 residues by Western blot analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
MAP kinase-interacting serine/threonine-protein kinase 2 (CHEMBL4204) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Targeting the immunity protein kinases for immuno-oncology.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.29 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4298140 | TOMIVOSERTIB HYDROCHLORIDE | 1.0 | 1 | 9.00 |
| CHEMBL4211649 | TINODASERTIB | 2.0 | 1 | 7.07 |
| CHEMBL1240885 | — | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4298140 | TOMIVOSERTIB HYDROCHLORIDE | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4211649 | TINODASERTIB | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL1240885 | — | IC50 | = | 1600.0 | nM | 5.80 |