Assay Detail
Binding
CHEMBL4331738
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PIM1 (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase pim-1 (CHEMBL2147) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Targeting the immunity protein kinases for immuno-oncology.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.78 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2048872 | — | — | 1 | 9.40 |
| CHEMBL1952329 | SGI-1776 | 1.0 | 1 | 8.15 |
| CHEMBL3651966 | LGH-447 | 1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2048872 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL1952329 | SGI-1776 | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3651966 | LGH-447 | IC50 | = | 0.006 | nM | - |