Assay Detail
Binding
CHEMBL4331742
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Inhibition of human N-terminal His-tagged PI3Kalpha/p85alpha expressed in Spodoptera frugiperda using phosphatidylinositol as substrate
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Targeting the immunity protein kinases for immuno-oncology.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.87 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2216870 | IDELALISIB | 4.0 | 1 | 6.10 |
| CHEMBL4450504 | — | — | 1 | 5.64 |
| CHEMBL2216863 | DEZAPELISIB | 2.0 | 1 | - |
| CHEMBL3948730 | UMBRALISIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2216870 | IDELALISIB | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4450504 | — | IC50 | = | 2299.0 | nM | 5.64 |
| CHEMBL2216863 | DEZAPELISIB | IC50 | > | 10000.0 | nM | - |
| CHEMBL3948730 | UMBRALISIB | IC50 | > | 10000.0 | nM | - |