Assay Detail
Binding
CHEMBL4331744
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Inhibition of PI3Kgamma (unknown origin)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (CHEMBL3267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Targeting the immunity protein kinases for immuno-oncology.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.43 | 9.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3984425 | EGANELISIB | 2.0 | 1 | 9.54 |
| CHEMBL3039502 | DUVELISIB | 4.0 | 1 | 8.60 |
| CHEMBL568150 | — | — | 1 | 8.10 |
| CHEMBL2216870 | IDELALISIB | 4.0 | 1 | 7.20 |
| CHEMBL230011 | TG100-115 | 2.0 | 1 | 7.08 |
| CHEMBL3948730 | UMBRALISIB | 4.0 | 1 | 5.85 |
| CHEMBL2216863 | DEZAPELISIB | 2.0 | 1 | 5.64 |
| CHEMBL4450504 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3984425 | EGANELISIB | IC50 | = | 0.29 | nM | 9.54 |
| CHEMBL3039502 | DUVELISIB | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL568150 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL2216870 | IDELALISIB | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL230011 | TG100-115 | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL3948730 | UMBRALISIB | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL2216863 | DEZAPELISIB | IC50 | = | 2297.0 | nM | 5.64 |
| CHEMBL4450504 | — | IC50 | > | 10000.0 | nM | - |