Assay Detail
Binding
CHEMBL4331764
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Inhibition of human carbonic anhydrase-12 catalytic domain assessed as reduction in CO2 hydration after 15 mins by phenol red dye based stopped flow assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Exploring structural properties of potent human carbonic anhydrase inhibitors bearing a 4-(cycloalkylamino-1-carbonyl)benzenesulfonamide moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 8.16 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4533094 | — | — | 1 | 8.57 |
| CHEMBL4532154 | — | — | 1 | 8.51 |
| CHEMBL4450272 | — | — | 1 | 8.42 |
| CHEMBL4590763 | — | — | 1 | 8.35 |
| CHEMBL4453778 | — | — | 1 | 8.25 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 8.24 |
| CHEMBL4465705 | — | — | 1 | 8.19 |
| CHEMBL4437968 | — | — | 1 | 8.18 |
| CHEMBL4469954 | — | — | 1 | 8.14 |
| CHEMBL4462670 | — | — | 1 | 8.11 |
| CHEMBL4547604 | — | — | 1 | 8.11 |
| CHEMBL4553372 | — | — | 1 | 8.10 |
| CHEMBL4554983 | — | — | 1 | 8.09 |
| CHEMBL4441940 | — | — | 1 | 8.07 |
| CHEMBL4442611 | — | — | 1 | 8.07 |
| CHEMBL4593188 | — | — | 1 | 8.03 |
| CHEMBL4590736 | — | — | 1 | 7.23 |
| CHEMBL220492 | TOPIRAMATE | 4.0 | 1 | - |
| CHEMBL3613783 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4533094 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL4532154 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL4450272 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL4590763 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL4453778 | — | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL4465705 | — | Ki | = | 6.4 | nM | 8.19 |
| CHEMBL4437968 | — | Ki | = | 6.6 | nM | 8.18 |
| CHEMBL4469954 | — | Ki | = | 7.3 | nM | 8.14 |
| CHEMBL4462670 | — | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL4547604 | — | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL4553372 | — | Ki | = | 7.9 | nM | 8.10 |
| CHEMBL4554983 | — | Ki | = | 8.1 | nM | 8.09 |
| CHEMBL4441940 | — | Ki | = | 8.5 | nM | 8.07 |
| CHEMBL4442611 | — | Ki | = | 8.5 | nM | 8.07 |
| CHEMBL4593188 | — | Ki | = | 9.4 | nM | 8.03 |
| CHEMBL4590736 | — | Ki | = | 59.4 | nM | 7.23 |
| CHEMBL220492 | TOPIRAMATE | Ki | - | — | - | |
| CHEMBL3613783 | — | Ki | - | — | - |