Assay Detail
Binding
CHEMBL4331765
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Inhibition of human carbonic anhydrase-14 catalytic domain assessed as reduction in CO2 hydration after 15 mins by phenol red dye based stopped flow assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Exploring structural properties of potent human carbonic anhydrase inhibitors bearing a 4-(cycloalkylamino-1-carbonyl)benzenesulfonamide moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 7.48 | 8.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4442611 | — | — | 1 | 8.11 |
| CHEMBL4554983 | — | — | 1 | 8.11 |
| CHEMBL4465705 | — | — | 1 | 7.96 |
| CHEMBL4532154 | — | — | 1 | 7.86 |
| CHEMBL4453778 | — | — | 1 | 7.82 |
| CHEMBL4553372 | — | — | 1 | 7.62 |
| CHEMBL4590736 | — | — | 1 | 7.53 |
| CHEMBL4462670 | — | — | 1 | 7.50 |
| CHEMBL4450272 | — | — | 1 | 7.46 |
| CHEMBL4533094 | — | — | 1 | 7.42 |
| CHEMBL3613783 | — | — | 1 | 7.41 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.39 |
| CHEMBL4590763 | — | — | 1 | 7.38 |
| CHEMBL4469954 | — | — | 1 | 7.38 |
| CHEMBL4441940 | — | — | 1 | 7.37 |
| CHEMBL4437968 | — | — | 1 | 7.33 |
| CHEMBL4547604 | — | — | 1 | 7.28 |
| CHEMBL4593188 | — | — | 1 | 7.27 |
| CHEMBL220492 | TOPIRAMATE | 4.0 | 1 | 5.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4442611 | — | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL4554983 | — | Ki | = | 7.7 | nM | 8.11 |
| CHEMBL4465705 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL4532154 | — | Ki | = | 13.7 | nM | 7.86 |
| CHEMBL4453778 | — | Ki | = | 15.2 | nM | 7.82 |
| CHEMBL4553372 | — | Ki | = | 23.8 | nM | 7.62 |
| CHEMBL4590736 | — | Ki | = | 29.8 | nM | 7.53 |
| CHEMBL4462670 | — | Ki | = | 31.4 | nM | 7.50 |
| CHEMBL4450272 | — | Ki | = | 34.6 | nM | 7.46 |
| CHEMBL4533094 | — | Ki | = | 37.9 | nM | 7.42 |
| CHEMBL3613783 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL4590763 | — | Ki | = | 41.7 | nM | 7.38 |
| CHEMBL4469954 | — | Ki | = | 41.5 | nM | 7.38 |
| CHEMBL4441940 | — | Ki | = | 42.8 | nM | 7.37 |
| CHEMBL4437968 | — | Ki | = | 46.9 | nM | 7.33 |
| CHEMBL4547604 | — | Ki | = | 52.5 | nM | 7.28 |
| CHEMBL4593188 | — | Ki | = | 53.7 | nM | 7.27 |
| CHEMBL220492 | TOPIRAMATE | Ki | = | 1460.0 | nM | 5.84 |