Assay Detail
Functional
CHEMBL4332085
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MCF7 cells assessed as reduction in cell proliferation measured after 5 days by Cell-titer-Glo assay
63
Total Activities
63
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Selective estrogen receptor degraders with novel structural motifs induce regression in a tamoxifen-resistant breast cancer xenograft.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 63 | 7.88 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1358 | FULVESTRANT | 4.0 | 1 | 9.22 |
| CHEMBL4474820 | — | — | 1 | 9.15 |
| CHEMBL4527199 | — | — | 1 | 9.05 |
| CHEMBL4464136 | — | — | 1 | 9.05 |
| CHEMBL4563585 | — | — | 1 | 8.85 |
| CHEMBL4442838 | — | — | 1 | 8.74 |
| CHEMBL4448909 | — | — | 1 | 8.68 |
| CHEMBL4559957 | — | — | 1 | 8.66 |
| CHEMBL3581693 | BRILANESTRANT | 2.0 | 1 | 8.60 |
| CHEMBL4577104 | — | — | 1 | 8.59 |
| CHEMBL4531707 | — | — | 1 | 8.54 |
| CHEMBL4456861 | — | — | 1 | 8.54 |
| CHEMBL4455921 | — | — | 1 | 8.54 |
| CHEMBL4472714 | — | — | 1 | 8.52 |
| CHEMBL4562048 | — | — | 1 | 8.38 |
| CHEMBL4582772 | — | — | 1 | 8.37 |
| CHEMBL4560511 | — | — | 1 | 8.36 |
| CHEMBL4455108 | — | — | 1 | 8.36 |
| CHEMBL195515 | — | — | 1 | 8.34 |
| CHEMBL4552977 | — | — | 1 | 8.30 |
| CHEMBL4519174 | — | — | 1 | 8.29 |
| CHEMBL4444687 | — | — | 1 | 8.29 |
| CHEMBL4531957 | — | — | 1 | 8.23 |
| CHEMBL4440665 | — | — | 1 | 8.16 |
| CHEMBL3581641 | — | — | 1 | 8.14 |
| CHEMBL4437503 | — | — | 1 | 8.14 |
| CHEMBL4561552 | — | — | 1 | 8.12 |
| CHEMBL4513432 | — | — | 1 | 8.04 |
| CHEMBL4451352 | — | — | 1 | 7.96 |
| CHEMBL4457003 | — | — | 1 | 7.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1358 | FULVESTRANT | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL4474820 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL4464136 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL4527199 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL4563585 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4442838 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL4448909 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL4559957 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL3581693 | BRILANESTRANT | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL4577104 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL4531707 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL4456861 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL4455921 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL4472714 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4562048 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL4582772 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL4560511 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL4455108 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL195515 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL4552977 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4519174 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL4444687 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL4531957 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL4440665 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL4437503 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL3581641 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL4561552 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL4513432 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL4451352 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4457003 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4474494 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4467689 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4460153 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4572383 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4554587 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4436368 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL4521219 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4568824 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL4462781 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4475951 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL4435583 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4563996 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL4542877 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4556145 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4520785 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4473222 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4553383 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4437988 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL4475225 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4454739 | — | IC50 | = | 380.0 | nM | 6.42 |