Assay Detail
Binding
CHEMBL4332214
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of chemotaxis after 30 mins by Celltiter-glo reagent based luminescence assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of novel azaindazole CCR1 antagonist clinical candidates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.59 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4464625 | — | — | 1 | 9.52 |
| CHEMBL4456123 | BI 639667 | 1.0 | 1 | 8.70 |
| CHEMBL4441094 | — | — | 1 | 7.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4464625 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL4456123 | BI 639667 | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4441094 | — | IC50 | = | 28.0 | nM | 7.55 |