Assay Detail
Binding
CHEMBL4332295
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of VEGFR1 (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 1 (CHEMBL1868) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The association between anti-tumor potency and structure-activity of protein-kinases inhibitors based on quinazoline molecular skeleton.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.58 | 8.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4539051 | — | — | 1 | 8.26 |
| CHEMBL4589270 | — | — | 1 | 8.15 |
| CHEMBL4548316 | — | — | 1 | 8.02 |
| CHEMBL4578561 | — | — | 1 | 5.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4539051 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL4589270 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL4548316 | — | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL4578561 | — | IC50 | = | 1255.0 | nM | 5.90 |