Assay Detail
Functional
CHEMBL4332360
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HCC827 cells harboring EGFR L858R mutant after 72 hrs by CCK8 assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCC827 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of new quinazoline derivatives as irreversible dual EGFR/HER2 inhibitors and their anticancer activities - Part 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 8.91 | 9.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4457295 | — | — | 1 | 9.82 |
| CHEMBL4549345 | — | — | 1 | 9.82 |
| CHEMBL4577883 | — | — | 1 | 9.57 |
| CHEMBL4474073 | — | — | 1 | 9.54 |
| CHEMBL4473875 | — | — | 1 | 9.51 |
| CHEMBL4443188 | — | — | 1 | 9.47 |
| CHEMBL4577402 | — | — | 1 | 9.47 |
| CHEMBL1173655 | AFATINIB | 4.0 | 1 | 9.36 |
| CHEMBL4442324 | — | — | 1 | 9.28 |
| CHEMBL4456662 | — | — | 1 | 9.28 |
| CHEMBL4592101 | — | — | 1 | 9.26 |
| CHEMBL4450824 | — | — | 1 | 9.26 |
| CHEMBL4577968 | — | — | 1 | 9.01 |
| CHEMBL4591886 | — | — | 1 | 8.88 |
| CHEMBL4473690 | — | — | 1 | 8.84 |
| CHEMBL4447976 | — | — | 1 | 8.60 |
| CHEMBL4465139 | — | — | 1 | 8.54 |
| CHEMBL4456300 | — | — | 1 | 8.46 |
| CHEMBL4556389 | — | — | 1 | 8.40 |
| CHEMBL4441788 | — | — | 1 | 8.31 |
| CHEMBL4557964 | — | — | 1 | 8.26 |
| CHEMBL4560518 | — | — | 1 | 8.19 |
| CHEMBL4591414 | — | — | 1 | 8.11 |
| CHEMBL4468146 | — | — | 1 | 8.11 |
| CHEMBL4589070 | — | — | 1 | 7.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4457295 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL4549345 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL4577883 | — | IC50 | = | 0.27 | nM | 9.57 |
| CHEMBL4474073 | — | IC50 | = | 0.29 | nM | 9.54 |
| CHEMBL4473875 | — | IC50 | = | 0.31 | nM | 9.51 |
| CHEMBL4443188 | — | IC50 | = | 0.34 | nM | 9.47 |
| CHEMBL4577402 | — | IC50 | = | 0.34 | nM | 9.47 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 0.4376 | nM | 9.36 |
| CHEMBL4442324 | — | IC50 | = | 0.53 | nM | 9.28 |
| CHEMBL4456662 | — | IC50 | = | 0.53 | nM | 9.28 |
| CHEMBL4592101 | — | IC50 | = | 0.55 | nM | 9.26 |
| CHEMBL4450824 | — | IC50 | = | 0.55 | nM | 9.26 |
| CHEMBL4577968 | — | IC50 | = | 0.987 | nM | 9.01 |
| CHEMBL4591886 | — | IC50 | = | 1.31 | nM | 8.88 |
| CHEMBL4473690 | — | IC50 | = | 1.46 | nM | 8.84 |
| CHEMBL4447976 | — | IC50 | = | 2.54 | nM | 8.60 |
| CHEMBL4465139 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL4456300 | — | IC50 | = | 3.43 | nM | 8.46 |
| CHEMBL4556389 | — | IC50 | = | 3.95 | nM | 8.40 |
| CHEMBL4441788 | — | IC50 | = | 4.86 | nM | 8.31 |
| CHEMBL4557964 | — | IC50 | = | 5.56 | nM | 8.26 |
| CHEMBL4560518 | — | IC50 | = | 6.39 | nM | 8.19 |
| CHEMBL4591414 | — | IC50 | = | 7.81 | nM | 8.11 |
| CHEMBL4468146 | — | IC50 | = | 7.78 | nM | 8.11 |
| CHEMBL4589070 | — | IC50 | = | 33.22 | nM | 7.48 |