Assay Detail
Functional
CHEMBL4332396
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Antiproliferative activity against human A549 cells after 72 hrs by CCK-8 assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of a new class of valosine containing protein (VCP/P97) inhibitors for the treatment of non-small cell lung cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.66 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3747513 | CB-5083 | 1.0 | 1 | 5.89 |
| CHEMBL4461505 | — | — | 1 | 5.80 |
| CHEMBL4451017 | — | — | 1 | 5.68 |
| CHEMBL4455739 | — | — | 1 | 5.58 |
| CHEMBL4453010 | — | — | 1 | 5.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3747513 | CB-5083 | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4461505 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4451017 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4455739 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4453010 | — | IC50 | = | 4600.0 | nM | 5.34 |