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Assay Detail

CHEMBL4333072

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ADMET
Cytotoxicity against CHOK1 cells
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Cricetulus griseus
Cell Type CHO-K1
Confidence 1 — Organism
Curated By Autocuration

Target

CHO-K1 (CHEMBL614031)
Type CELL-LINE
Organism Cricetulus griseus

Publication

Discovery of Novel Pyruvate Dehydrogenase Kinase 4 Inhibitors for Potential Oral Treatment of Metabolic Diseases.
Lee D, Pagire HS, Pagire SH, Bae EJ, Dighe M, Kim M, Lee KM, Jang YK, Jaladi AK, Jung KY, Yoo EK, Gim HE, Lee S, Choi WI, Chi YI, Song JS, Bae MA, Jeon YH, Lee GH, Liu KH, Lee T, Park S, Jeon JH, Lee IK, Ahn JH.
J Med Chem (2019) 62 : 575 -588
PubMed 30623649 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 4.44 4.44

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4471264 1 4.44

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4471264 IC50 = 36020.0 nM 4.44